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KMID : 1100220160150020055
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Dementia and Neurocognitive Disorders
2016 Volume.15 No. 2 p.55 ~ p.58
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Corticobasal Degeneration Presenting as Non-Fluent/Agrammatic Primary Progressive Aphasia: A Case Report
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Kim Ji-Sun
Lee Geum-Bong
Hong Yun-Jeong
Park Kyung-Won
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Abstract
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Background : Non-fluent agrammatic primary progressive aphasia (naPPA) is characterized by progressive non-fluent speech disorder and might be associated with taupathy such as corticobasal degeneration (CBD) and progressive supranuclear palsy. We report a case of overlap syndrome presented with language impairment, and diagnosed as naPPA with possible CBD.
Case Report ; A 58-year-old woman visited a memory and dementia clinic, with a 10-month history of progressive language disturbance. She was diagnosed as naPPA and overlapping CBD, based on the clinical features and neuroimaging findings including florbetaben PET.
Conclusions ; naPPA is pathologically caused by taupathy, and might progress to asymmetrical parkinsonism and apraxia, suggestive of CBD. Overlapping clinical features in our case represent various phenotypes of taupathy.
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KEYWORD
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non-fluent agrammatic primary progressive aphasia, taupathy, corticobasal degeneration
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